Molecular Biology: Macromolecular Synthesis and Cellular Function

Molecular biology of prokaryotic and eukaryotic cells and their viruses. Mechanisms of DNA replication, transcription, translation. Structure of genes and chromosomes. Regulation of gene expression. Biochemical processes and principles in membrane structure and function, intracellular trafficking and subcellular compartmentation, cytoskeletal architecture, nucleocytoplasmic transport, signal transduction mechanisms, and cell cycle control.

Lectures

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   Lecture 1 - Nucleic acid products of Polymerase Machines

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   Lecture 2 - The DNA replication fork: collaborate or die

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   Lecture 3 - DNA Polymerase Holoenzyme

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   Lecture 4 - The Ends of Eucaryotic Chromosomes

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   Lecture 5 - A Simple Cloning Procedure

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   Lecture 6 - Genome Resequencing

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   Lecture 7 - Histones

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   Lecture 8 - Genome Structures: What's in a Model Organism?

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   Lecture 9 - Genomics and bioinformatics:Time Machines and Functions

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    Lecture 10 - Human disease genes: risky science and the new infinity

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    Lecture 11 - DNA Damage and Repair: oops, ouch

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    Lecture 12 - Flow of Biological Information

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    Lecture 13 - Flow of Biological Information continued

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    Lecture 14 - Regulation of Prokaryotic Transcription

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    Lecture 15 - Regulation of Prokaryotic Transcription continued

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    Lecture 16 - Three types of RNA polymerase in Eukaryotic nuclei

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    Lecture 17 - TBP (TATA-boxbinding protein)

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    Lecture 18 - Gel Shift Assay

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    Lecture 19 - Eukaryotic Transcription Control

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    Lecture 20 - Hyperacylation of Histones

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    Lecture 21 - Cromatin immunoprecipitation (ChIP) Method

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    Lecture 22 - Multiple ways of regulating the regulators

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    Lecture 23 - RNA Processing

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    Lecture 24 - Alternative Splicing

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    Lecture 25 - Initiation of Prokaryotic Translation

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    Lecture 26 - Systems to Study biology

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    Lecture 27 - Membrane Structures

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    Lecture 28 - Types of Membrane Proteins

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    Lecture 29 - Molecular Biology of the Cell

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    Lecture 30 - Intracellular Vesicular Traffic

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    Lecture 31 - Rab-Ras associated Binding Protein

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    Lecture 32 - Mechanisms of cell Communication

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    Lecture 33 - Myostatin

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    Lecture 34 - Cytoskeletin

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    Lecture 35 - Programmed Cell Death

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    Lecture 36 - Autophagy