decision-making
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The bubonic plague is the measure by which succeeding epidemics have long been measured. Its extreme virulence, horrible symptoms, and indiscriminate victim profile all contributed to making plague the archetypical worst-case scenario. For these same reasons, the plague is also an ideal test case for the thesis that epidemic diseases play a major role in shaping human history. Over the course of its three pandemics, the plague had major ec...more
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Loss of sensory or behavioural functions as a result of brain damage or dysfunction can clearly have a significant negative impact on quality of life. What progress are we making towards repairing damaged brains and sense organs and treating mental disorders? This lecture will consider what therapeutic promise is currently offered by pharamacological, brain stimulation, brain training, neuroprosthetic (connecting artificial sensors to...more
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eBay is in 28 countries and the company is looking into cost effective ways to enter new markets, says Reedy. PayPal will attack Europe next year. Typically, eBay, being global, can enter new countries easily; in the case of PayPal it will take more effort. When making an acquisition eBay lets the business strategy define the process or platform. Over time they look for ways to move the country onto the platform as long as it does not put ...more
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Today's lecture concludes Professor Freeman's discussion of the four phases of the Revolutionary War. America's victory at the Battle of Saratoga in 1777 marked the end of the third phase of the war, and led to a turning point in the conflict: France's decision to recognize American independence and enter into an alliance with the fledging nation. Although the British made one final attempt at reconciliation in 1778 with the Conciliatory P...more
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Rodrigo Jordan, Founder of Vertical, describes a challenge in making the first crossing of the Ellsworth Mountains in Antarctica, highlighting the role in optimism in allowing the team to shift their paradigm and successfully cross an ice valley. Jordan then argues that the entrepreneurs he admires have a similar, paradigm shifting optimism: despite the challenges and disappointments that his colleagues inevitably face, these entrepreneurs...more
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Rick Wallace, the new CEO of KLA-Tencor shares his insights about managing a large organization. He describes his job as making trade-offs to ensure that all three constituents, investors, customers and employees, are happy with the company. While they all have separate and sometimes contradicting motivations, a company's long term success is heavily dependant on its ability to cater to these three constituencies.
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In this lecture, Professor Freeman discusses the Declaration of Independence and sets the document in its historical context. The Declaration was not the main focus of the Second Continental Congress, which was largely concerned with organizing the defensive war effort. The Congress had sent King George III the Olive Branch Petition in a last attempt at reconciliation in August 1775, but the King ignored the petition and declared the colon...more
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Roizen talks about the importance of bootstrapping and maintaining control of the company in the early stages. Not only do entrepreneurs have to work for a living, they also have to make the money raised last for a longer time. When capital became easily available, Roizen notes that people stop making money the old fashion way: by working. If you make profit, you don't need other people to invest in your company, she says.
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Reedy talks about the leadership characteristics at eBay - understanding the eBay DNA, always creating a compelling sense of purpose, setting clear objectives, building a strong team, knowing how to prioritize, how to multi task and understand when you need to have a sense of urgency, diving deep and solving problems quickly, making and meeting commitments, leading and not being a victim. As a leader, she says, you have to have the right s...more
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English Architecture: Making England in the Shadow of Rome, 410-1130
Gresham College / Art & Architecture
When the English nation rose out of the ruins of the Roman Province of Britannia, people remained obsessed with their Roman past. Seismic social and political change in 1066 barely upset the vision of patrons and architects and Rome remained England's cultural capital driving the imagination of its architects.
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Armen Berjikly, Founder and CEO of Experience Project, shares the basic concept behind the company: a portal for people to share experiences with others in a similar situation. He illustrates by giving an example of a young mother diagnosed with breast cancer. He notes that his portal offered her an opportunity to talk to people who had similar experiences and thereby making her journey less painful.
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The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryngologist Dr. Dianne Duffey provides a clinician's perspective on the testing and marketing of pharmaceuticals, on the FDA approval process, on clinical trial system, on off-label uses, and on ...more
