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  1. According to Wirt, PDAs have evolved over the last decade from just an address book and calendar to devices that can play movies and MP3s and carry much more information.  In the next decade, he sees an increased ability to carry around many types of information.

  2. After discussing the four key elements of any entrepreneurial venture (people, opportunity, context and deal), William Sahlman, professor at Harvard Business School, argues that the greatest value can be achieved by "changing the game," that is changing the relationship of the core elements to one another. Sahlman illustrates this strategy with the example of John Osher and the spin toothbrush. To change the game, Osher brought in the...more

  3. Yock talks about the Biotech bay - the other Silicon Valley, and how the products offered are based on the science of genetics. Medtech focuses on instruments, equipments, and is not a trivial market sector, he says. The Bay has titans like J&J, Guidant, and Boston scientific, for example. There is significant start up funding into the Medtech sector. Half to two thirds of venture funding for Medtech goes into Northern California, he adds.

  4. Danger was able to break into the US market by convincing wireless carriers to adopt a fixed rate pricing scheme for the device, which is almost essential in the minds of Americans for using services like AIM and web surfing.  The Asian and European markets are further ahead and calls are cheaper, making it more difficult for the Hiptop to be profitable.

  5. Innovation will drive the next cycle, says Estrin. Startups don't succeed in validated markets; the role of startups is to create a new market, she says. As an entrepreneur, you have be able to take that risk in an unvalidated market, she adds.

  6. Yock sees tremendous theoretical progress for nanotechnology. However, he does not see the first hand hold at least in the cardio vascular area.

  7. The applications for the Fluidigm technology may be far from being realized, says Worthington.  Fluidigm is currently working on high-throughout methodologies, like genome screening and protein-protein interactions, as well as what could turn out to be breakthrough science: using  rubber pumps to simulate body functions to trick cells into thinking they are inside the body, he says.

  8. During its inception, Dell explains how the computer industry was run by engineers. Over a thirty-year period however, customers began to have an important role in the industry, but many companies were still being run by engineers working to promote complexity. With complicated products being sold, says Dell, customers had to rent specialized software and hire consultants from the computer companies to get their products to work. As a...more

  9. Google will always be a search engine, despite any additional directions the company may take, because it is a critical part of the mission the founders Page and Brin have defined. Also, says the company, the search engine is far from perfect and still requires many developments before it is complete.

  10. Priceline co-founder Jesse Fink explains to entrepreneur Steve Blank how his early company was a technology-enhanced solution to a business model - and not a real technology play - that succeeded in providing for both business and consumer. Fink brings these same solutions to his current investment firm, MissionPoint, who believes it will be business models and capital markets that find environmental solutions, and not the technology itself.

  11. John Simpson, a Stanford trainee in cardiology, thought the catheter system didn't work so he worked in his kitchen in Menlo Park to develop a catheter that is easier to use. He used a guidewire to travel down into the coronary artery . With money from Fogarty and Ray Williams, an angel investor, he started a company called ACS, which grew into Guidant.

  12. After his company zip2, Musk started exploring other opportunities on the web. He realized that money required low bandwidth and there was not enough innovation in the financial industry. Musk shares how he arrived at the idea of PayPal.