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  1. Komisar explains how the original TiVO concept went through multiple transformations. Originally, the TiVO entrepreneurs wanted to create a stand-alone VCR box that would be sold by large retailers. Over time and with the guidance of Komisar, the entrepreneurs realized it would make better sense to offer TiVo as a service instead of a hardware product with low-margins.

  2. Ringold talks about Surromed's goals: 1) To improve the use of existing drugs and diagnostics 2) Right medicine for the right patient in the right dose at the right time. Ringold talks in detail about the limitations of diagnostic techniques and drug use today and how Surromed tries to find a solution to some of the problems. He shares a report by McKinsey which summarizes the status of drug discovery.

  3. Medtronic, Boston Scientific, and Johnson & Johnson all began as single-product ventures, says Mir Imran, CEO of InCube Labs and serial entrepreneur of medical devices. And while the medical community is rife with single-product ventures, a few of them do go on to become large enterprises offering a suite of products in multiple markets. What sets the bar for each venture? The market viability for each product they produce.

  4. Eisenhardt discusses the ideal markets for start-ups. She classifies them into emergent, growth and mature. Emergent markets are typically small and undefined, growth markets are between $30M-$50M with a high growth rate and mature markets are > $100M. She suggests that the ideal market for a company to start in is a growth market.

  5. Thompson talks about how the most significant event for the security space was not 9/11 but it was 9/18. That is the day a dangerous virus, nimda, hit.

  6. Yock talks about the fundamental problem of applying the balloon technology to dilating the heart narrowing. The balloon was too compliant. He talks about the development of a balloon that actually worked.

  7. Musk talks about the restrictions on space travel due to the government involvement. He shares some examples of these restrictions.

  8. Reedy shares a commercial that is going to air later in the week. She talks about eBay's vision - providing a global online trading platform - and the value proposition - making inefficient markets efficient by bring back the fun and the passion.

  9. When things are hot, that's not the area to invest, Khosla cautions. There is a surprise element always present where the biggest opportunities lie. Khosla highlights his interests in biology, genetics, nanotechnology and optical technology.

  10. In Kawasaki's opinion, he discusses the 10 reasons why Silicon Valley 4.0 will never happen.

  11. Erin Turner, a producer at Electronic Arts specializing in action-hero titles, explains that the GameBoy has a pretty substantial market with 40 million sold worldwide.  The mission with the GameBoy is to create some unique draw or additional fun factor, since it does not have nearly the graphical capabilities as a console, she says.  The team's challenge is to provide the optimal gaming experience, while working within the constraints of ...more

  12. According to Wirt, PDAs have evolved over the last decade from just an address book and calendar to devices that can play movies and MP3s and carry much more information.  In the next decade, he sees an increased ability to carry around many types of information.