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The major market for the AIDS vaccine is in the developing world, says Francis, but there is significant demand in the United States with 40,000 new cases a year. There are a lot of unknowns in the business climate in the United States affecting the profitability of a vaccine. It is difficult to encourage investment when a blockbuster drugs would have a much higher rate of return, he adds.
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The global AIDS pandemic furnishes a case study for many of the themes addressed throughout the course. While in the developed West the disease largely afflicts concentrated high-risk groups such as intravenous drug users and the sexually promiscuous, in Southern Africa it is much more a generalized disease of poverty. In countries such as Botswana and Swaziland, the economic and social consequences of the disease have created a vicious ci...more
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Randy has learned from years of starting companies that he has developed an addiction to risk taking. A benefit of young companies is that it is easier to take risks because of the size. There may be nay-sayers, but Randy's advice is to ignore them and continue on with your plan.
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This course offers a holistic view of the aircraft as a system, covering: basic systems engineering; cost and weight estimation; basic aircraft performance; safety and reliability; lifecycle topics; aircraft subsystems; risk analysis and management; and system realization. Small student teams retrospectively analyze an existing aircraft covering: key design drivers and decisions; aircraft attributes and subsystems; and operational experien...more
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This lecture completes the first half of the semester by analyzing three functional groups in terms of the interaction of localized atomic or pairwise orbitals. Many key properties of biological polypeptides derive from the mixing of such localized orbitals that we associate with "resonance" of the amide group. The acidity of carboxylic acids and the aggregation of methyl lithium into solvated tetramers can be understood in analogous terms...more
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Bush and 9/11 Put AIDS on the Back Burner - And a New Social Venture is Born
Stanford / Entrepreneurship
Francis talks about how after 9/11, the government became interested in vaccines. Vaxgen shifted to making a small pox vaccine and an anthrax vaccine and has been very successful in these pursuits. Unfortunately, AIDS was not named as an immediate concern and was but on the back burner. Due to the unwillingness of both the government and private businesses to provide funding, Francis has now decided that the AIDS vaccine cannot be develo...more
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Chi-Square, Student-t, Multivariate Normal.
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July 26, 2007 presentation by Craig Heller for the Stanford University Office of Science Outreach's Summer Science Lecture Series. Craig Heller, Professor of Biological Sciences, shares how and why this novel technique is being developed and its potential to improve the quality of human life and the body's performance.
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Professor Shankar introduces the course and answers student questions about the material and the requirements. He gives an overview of Newtonian mechanics and explains its two components: kinematics and dynamics. He then reviews basic concepts in calculus through two key equations: x0 + v0t + ½ at2 and v2 = v02+ 2 a (x-x0), tracing the fate of a particle in one dimension along the x-axis.
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European populations grew only slowly during the period 1200-1700; factors include disease and wars. Human feces and rotting animal remains were not sequestered and often contaminated drinking water. Cities were so filthy that more people died in them than were born. About a third of children died in infancy, many from abandonment and lack of care during wet-nursing. Children that survived were subjected to harsh discipline to control thei...more
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October 26, 2007 lecture by Paul Tang for the Stanford University Human-Computer Interaction Seminar. Even more fragmented than American health care is the management of health care information. Faced with a barrage of poorly organized health information, physicians and other clinicians must sift through uninspired displays to glean pearls of information necessary to make clinical decisions. New tools for information gathering from patient...more
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Half a century before direct experimental observation became possible, most structures of organic molecules were assigned by inspired guessing based on plausibility. But Wilhelm Körner developed a strictly logical system for proving the structure of benzene and its derivatives based on isomer counting and chemical transformation. His proof that the six hydrogen positions in benzene are equivalent is the outstanding example of this chemical...more
